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KMID : 1161420160190060549
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Journal of Medicinal Food
2016 Volume.19 No. 6 p.549 ~ p.559
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Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein Kinase α Pathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease
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Hong Ji-Hye
Kim Se-Ra
Kim Hyun-Sook
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Abstract
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Nonalcoholic fatty liver disease (NAFLD), which is characterized by >5% deposition of triglycerides in hepatocytes, is often referred as a major risk factor for obesity, type 2 diabetes, and hypertension. We investigated the hepatoprotective effect of whole soybean embryos containing bioactive substances such as isoflavones and soyasaponins. For this study, mice were randomly allocated into four groups that were fed different diets for 10 weeks: normal diets and high-fat and high-cholesterol diets (HD), and HD with 10% or 20% soybean embryo powder (10SE-HD and 20SE-HD). Hepatic superoxide dismutase and glutathione peroxidase activity of the experimental groups increased during the period of the study (P?
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KEYWORD
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adiponectin, AMP-activated protein kinase, antioxidant activity, lipid metabolism, nonalcoholic fatty liver disease, soybean embryo
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